Structure via PubChem · Public domain (PubChem)
dyclonine
Sign in to saveAlso known as dyclocaine, 4-butoxy-beta-piperidinopropiophenone, 4-n-butoxy-beta-(1-piperidyl)propiophenone, 2-(1-piperidyl)ethyl p-butoxyphenyl ketone, 4'-butoxy-3-piperidinopropiophenone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanone, 3-piperidino-4'-butoxypropiophenone, Dyclonin
Dyclonine (Dyclocaine) is an oral anaesthetic that is the active ingredient of Sucrets, an over-the-counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.
Chemical data
- Formula
- C18H27NO2
- Molecular weight
- 289.4 g/mol
- IUPAC name
- 1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one
- SMILES
- CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2
- InChIKey
- BZEWSEKUUPWQDQ-UHFFFAOYSA-N
- XLogP
- 3.6
- Polar surface area
- 29.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- topical
via ChEMBL · EBI
Research
88 papers- Dyclonine.2006
- Dyclonine relieves the Parkinson's disease progression in rotenone-induced Drosophila model.Behavioural brain research · 2023
- Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair.Nature communications · 2024
- Dyclonine inhibition of TRPV3: From functional discovery to structural insight.Cell calcium · 2022
- A new horizon for the anesthetic drug dyclonine.Biochemical pharmacology · 2026
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 289.204179
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₈H₂₇NO₂
- subject has role
- local anesthetic
- medical condition treated
- pharyngitis
- canonical SMILES
- CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2
- World Health Organisation international non-proprietary name
- dyclonine
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- History
- See also
- References
- External links
Dyclonine (Dyclocaine) is an oral anaesthetic that is the active ingredient of Sucrets, an over-the-counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.
==History== The product Sucrets was introduced in Baltimore, Maryland, by Sharp & Dohme in 1932.
Excerpted from Wikipedia’s “dyclonine” article, available under the CC BY-SA 4.0 licence.