E4F1

Name

E4F transcription factor 1

Type

protein-coding

Position

2,223,440–2,235,743 (+)

Aliases

E4F

Ensembl

ENSG00000167967

RefSeq RNA

NM_001288776.2, NM_001288778.2, NM_004424.5, XM_005255155.2, XM_005255156.2

RefSeq protein

NP_001275705.2, NP_001275707.2, NP_004415.4, XP_005255212.1, XP_005255213.1

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014].

via MyGene.info

Gene · Ensembl

E4F transcription factor 1

Symbol

E4F1

Biotype

Protein coding

Organism

Homo sapiens

Location

16:2,223,440-2,235,743

Strand

Forward (+)

Assembly

GRCh38

• Transcription factor E4F1 as a regulator of cell life and disease progression.Science advances · 2023
• E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development.Nature communications · 2025
• The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.Nature communications · 2021
• E4F1 and ZNF148 are transcriptional activators of the -57A > C and wild-type TERT promoter.Genome research · 2023
• E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity.Proceedings of the National Academy of Sciences of the United States of America · 2016

via PubMed

Wikidata facts

via Wikidata · CC0