echinomycin
Sign in to saveAlso known as quinomycin A
thumb|Proposed enzymatic reaction mechanism for the biotransformation of 1 to 2. Echinomycin is a peptide antibiotic. It is a dimer of two peptides creating a cyclic structure. It contains a bicyclic aromatic chromophore that is attached to the dimerized cyclic peptide core and a thioacetal bridge. It intercalates into DNA at two specific sites, thereby blocking the binding of hypoxia inducible factor 1 alpha (HIF1alpha).
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- Biosynthesis
- References
thumb|Proposed enzymatic reaction mechanism for the biotransformation of 1 to 2. Echinomycin is a peptide antibiotic. It is a dimer of two peptides creating a cyclic structure. It contains a bicyclic aromatic chromophore that is attached to the dimerized cyclic peptide core and a thioacetal bridge. It intercalates into DNA at two specific sites, thereby blocking the binding of hypoxia inducible factor 1 alpha (HIF1alpha).
== Biosynthesis ==
Excerpted from Wikipedia’s “echinomycin” article, available under the CC BY-SA 4.0 licence.