EDC3
Sign in to saveAlso known as LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23
Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.
Gene data
EDC3- Name
- enhancer of mRNA decapping 3
- Type
- protein-coding
- Position
- 74,630,557–74,696,292 (−)
- Aliases
- LSM16, MRT50, YJDC, YJEFN2, hYjeF_N2-15q23
- Ensembl
- ENSG00000179151
- RefSeq RNA
- NM_001142443.3, NM_001142444.3, NM_001351378.2, NM_001351379.2, NM_025083.5
- RefSeq protein
- NP_001135915.1, NP_001135916.1, NP_001338307.1, NP_001338308.1, NP_079359.2
This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
enhancer of mRNA decapping 3
- Symbol
- EDC3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:74,630,557-74,696,292
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein EDC3 PDB 2VC8.png
Show 7 more facts
- HomoloGene ID
- 11827
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/80153
- genomic end
- 74988633
- genomic start
- 74922899
- chromosome
- human chromosome 15
- cytogenetic location
- 15q24.1
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.
EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]
Excerpted from Wikipedia’s “EDC3” article, available under the CC BY-SA 4.0 licence.