PRPF4
Sign in to saveAlso known as HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60, pre-mRNA processing factor 4
U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that is found in humans and encoded by the PRPF4 gene.
Gene data
PRPF4- Name
- pre-mRNA splicing tri-snRNP complex factor PRPF4
- Type
- protein-coding
- Aliases
- HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016].
via MyGene.info
Gene · Ensembl
pre-mRNA splicing tri-snRNP complex factor PRPF4
- Symbol
- PRPF4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:113,275,637-113,295,342
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that is found in humans and encoded by the PRPF4 gene.
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors.
Excerpted from Wikipedia’s “PRPF4” article, available under the CC BY-SA 4.0 licence.