EIF4EBP1
Sign in to saveAlso known as 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1
Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by the EIF4EBP1 gene. It inhibits cap-dependent translation by binding to translation initiation factor eIF4E. Phosphorylation of 4E-BP1 results in its release from eIF4E, thereby allows cap-dependent translation to continue thereby increasing the rate of protein synthesis.
Gene data
EIF4EBP1- Name
- eukaryotic translation initiation factor 4E binding protein 1
- Type
- protein-coding
- Position
- 38,030,494–38,060,380 (+)
- Aliases
- 4E-BP1, 4EBP1, BP-1, PHAS-I
- Ensembl
- ENSG00000187840
- RefSeq RNA
- NM_004095.4
- RefSeq protein
- NP_004086.1
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 4E binding protein 1
- Symbol
- EIF4EBP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:38,030,494-38,060,380
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- PDB 1wkw EBI.jpg
Show 7 more facts
- HomoloGene ID
- 3021
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1978
- genomic end
- 37917883
- genomic start
- 38030534
- chromosome
- human chromosome 8
- cytogenetic location
- 8p11.23
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Phosphorylation
- Function
- Interactions
- References
- Further reading
Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by the EIF4EBP1 gene. It inhibits cap-dependent translation by binding to translation initiation factor eIF4E. Phosphorylation of 4E-BP1 results in its release from eIF4E, thereby allows cap-dependent translation to continue thereby increasing the rate of protein synthesis.
== Phosphorylation == Phosphorylated 4E-BP1 is thought to be a marker of upstream signaling (mTOR) activation. 4E-BP1 has seven phospho-sites, the three most important of which are the initiation site Thr 37/Thr 46, the second site Thr 70, and the final site Ser65. Moreover, phosphorylation of Ser 65 and Thr 70 alone was not sufficient to block the inhibition of mRNA translation by 4E-BP1, suggesting that multiple phosphorylation events must be combined to increase the rate of protein synthesis.
Excerpted from Wikipedia’s “EIF4EBP1” article, available under the CC BY-SA 4.0 licence.