EIF5A

Also known as EIF-5A, EIF5A1, eIF5AI, eukaryotic translation initiation factor 5A, eIF-4D, FABAS

Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene.

Gene data

EIF5A

Name: eukaryotic translation initiation factor 5A
Type: protein-coding
Position: 7,306,944–7,312,466 (+)
Aliases: EIF-5A, EIF5A1, FABAS, eIF-4D, eIF5AI
Ensembl: ENSG00000132507
RefSeq RNA: NM_001143760.1, NM_001143761.1, NM_001143762.2, NM_001370420.1, NM_001370421.1
RefSeq protein: NP_001137232.1, NP_001137233.1, NP_001137234.1, NP_001357349.1, NP_001357350.1

Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]

Pathways

Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Hypusine synthesis from eIF5A-lysine Metabolism of proteins Post-translational protein modification Translation Factors eIF5A regulation in response to inhibition of the nuclear export system

via MyGene.info

Wikidata facts

Image: Protein EIF5A PDB 1FH4.png

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HomoloGene ID: 133803
exact match: identifiers.org/ncbigene/1984
genomic end: 7215774
genomic start: 7210318
cytogenetic location: 17p13.1

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Contents

Faundes-Banka syndrome
See also
References
Further reading

Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene.

It is the only known protein to contain the unusual amino acid hypusine [Nε-(4-amino-2-hydroxybutyl)-lysine], which is synthesized on eIF5A at a specific lysine residue from the polyamine spermidine by two catalytic steps.