MRPS6

Also known as C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6

protein-coding gene in the species Homo sapiens

Gene data

MRPS6

Name: mitochondrial ribosomal protein S6
Type: protein-coding
Position: 34,072,889–34,362,252 (+)
Aliases: C21orf101, MRP-S6, RPMS6, S6mt, bS6m
Ensembl: ENSG00000243927
RefSeq RNA: NM_032476.4
RefSeq protein: NP_115865.1

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008].