MRPL33

Also known as C2orf1, L33mt, MRP-L33, RPL33L, mitochondrial ribosomal protein L33

protein-coding gene in the species Homo sapiens

Gene data

MRPL33

Name: mitochondrial ribosomal protein L33
Type: protein-coding
Position: 27,771,683–27,781,484 (+)
Aliases: C2orf1, L33mt, MRP-L33, RPL33L, bL33m
Ensembl: ENSG00000243147
RefSeq RNA: NM_004891.4, NM_145330.3
RefSeq protein: NP_004882.1, NP_663303.1

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].