Structure via PubChem · Public domain (PubChem)
dropropizine
Sign in to saveDropropizine (or dipropizine) is a cough suppressant that is sold in Germany, Central America, South America, and some African countries such as Congo. It is sold as suppositories, tablets, and syrup. It is used to stop a cough caused by allergies or a cold.
Chemical data
- Formula
- C13H20N2O2
- Molecular weight
- 236.31 g/mol
- IUPAC name
- 3-(4-phenylpiperazin-1-yl)propane-1,2-diol
- SMILES
- C1CN(CCN1CC(CO)O)C2=CC=CC=C2
- InChIKey
- PTVWPYVOOKLBCG-UHFFFAOYSA-N
- XLogP
- 0.6
- Polar surface area
- 46.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- Cough, inflammation, rhinitis
via ChEMBL · EBI
Research
80 papers- Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review.Critical reviews in analytical chemistry · 2021
- Stereoselective pharmacokinetics and tissue distribution of levodropropizine after administration of pure levodropropizine and the rac-dropropizine to Sprague-Dawley rats.Xenobiotica; the fate of foreign compounds in biological systems · 2020
- Enantioselective LC-ESI-MS/MS determination of dropropizine enantiomers in rat plasma and application to a pharmacokinetic study.Biomedical chromatography : BMC · 2019
- Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough.The Journal of international medical research · 1995
- Antitussive therapy: A role for levodropropizine.Pulmonary pharmacology & therapeutics · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 236.152
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₃H₂₀N₂O₂
- canonical SMILES
- C1CN(CCN1CC(CO)O)C2=CC=CC=C2
- subject has role
- antitussive
- Commons category
- Dropropizine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Side effects
- See also
- References
Dropropizine (or dipropizine) is a cough suppressant that is sold in Germany, Central America, South America, and some African countries such as Congo. It is sold as suppositories, tablets, and syrup. It is used to stop a cough caused by allergies or a cold.
==Side effects== Adverse effects include drowsiness, nausea, heartburn, and respiratory depression.
Excerpted from Wikipedia’s “dropropizine” article, available under the CC BY-SA 4.0 licence.
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