EPHB2

Name

EPH receptor B2

Type

protein-coding

Position

22,710,798–22,921,500 (+)

Aliases

BDPLT22, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5

Ensembl

ENSG00000133216

RefSeq RNA

NM_001309192.2, NM_001309193.2, NM_004442.7, NM_017449.5, XM_006710441.5

RefSeq protein

NP_001296121.1, NP_001296122.1, NP_004433.2, NP_059145.2, XP_006710504.1

This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].

via MyGene.info

Gene · Ensembl

EPH receptor B2

Symbol

EPHB2

Biotype

Protein coding

Organism

Homo sapiens

Location

1:22,710,798-22,921,500

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein EPHB2 PDB 1b4f.png

via Wikidata · CC0