CSK

Also known as Src, c-src tyrosine kinase, CSK/Src, CSK, non-receptor tyrosine kinase, C-terminal Src kinase

protein-coding gene in the species Homo sapiens

Gene data

CSK

Name: C-terminal Src kinase
Type: protein-coding
Position: 74,782,023–74,804,177 (+)
Ensembl: ENSG00000103653
RefSeq RNA: NM_001127190.2, NM_001354988.2, NM_001387089.1, NM_001387090.1, NM_001387091.1
RefSeq protein: NP_001120662.1, NP_001341917.1, NP_001374018.1, NP_001374019.1, NP_001374020.1

The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017].