ERBB4
Sign in to saveAlso known as ALS19, HER4, p180erbB4, erb-b2 receptor tyrosine kinase 4
Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.
Gene data
ERBB4- Name
- erb-b2 receptor tyrosine kinase 4
- Type
- protein-coding
- Position
- 211,375,717–212,539,266 (−)
- Aliases
- ALS19, HER4, p180erbB4
- Ensembl
- ENSG00000178568
- RefSeq RNA
- NM_001042599.2, NM_001439005.1, NM_001439006.1, NM_005235.3, XM_006712364.4
- RefSeq protein
- NP_001036064.1, NP_001425934.1, NP_001425935.1, NP_005226.1, XP_006712427.1
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
erb-b2 receptor tyrosine kinase 4
- Symbol
- ERBB4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:211,375,717-212,539,266
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
- External links
Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.
== Function ==
Excerpted from Wikipedia’s “ERBB4” article, available under the CC BY-SA 4.0 licence.