ERCC4

Name

ERCC excision repair 4, endonuclease catalytic subunit

Type

protein-coding

Position

13,920,138–13,952,348 (+)

Aliases

ERCC11, FANCQ, RAD1, XFEPS, XPF

Ensembl

ENSG00000175595

RefSeq RNA

NM_005236.3, XM_011522424.4, XM_011522427.2, XM_047433774.1, XM_054379810.1

RefSeq protein

NP_005227.1, XP_011520726.1, XP_011520729.1, XP_047289730.1, XP_054235785.1

The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009].

via MyGene.info

Gene · Ensembl

ERCC excision repair 4, endonuclease catalytic subunit

Symbol

ERCC4

Biotype

Protein coding

Organism

Homo sapiens

Location

16:13,920,138-13,952,348

Strand

Forward (+)

Assembly

GRCh38

Protein · UniProt

Cell cycle checkpoint protein RAD1

Gene

RAD1

Organism

Homo sapiens (Human)

Length

282 aa

Molecular mass

31,827 Da

Evidence

1: Evidence at protein level

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proce…

Wikidata facts

Instance of

protein

Image

Protein ERCC4 PDB 1z00.png

via Wikidata · CC0