ERCC4

Also known as ERCC11, FANCQ, RAD1, XPF, XFEPS, excision repair cross-complementation group 4, ERCC excision repair 4, endonuclease catalytic subunit, RAD1 checkpoint DNA exonuclease

gene da espécie Homo sapiens

In the Vinony graph

Vinony's link graph records 73 inbound references to ERCC4, and connects out to Wikidata, PubMed and DNA repair.

It sits within the topics Genes on human chromosome 5 and Human proteins.

Vinony links it to 7 Wikipedia language editions.

Gene data

ERCC4

Name: ERCC excision repair 4, endonuclease catalytic subunit
Type: protein-coding
Position: 13,920,138–13,952,348 (+)
Aliases: ERCC11, FANCQ, RAD1, XFEPS, XPF
Ensembl: ENSG00000175595
RefSeq RNA: NM_005236.3, XM_011522424.4, XM_011522427.2, XM_047433774.1, XM_054379810.1
RefSeq protein: NP_005227.1, XP_011520726.1, XP_011520729.1, XP_047289730.1, XP_054235785.1

The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009].

Pathways

Nucleotide excision repair - Homo sapiens (human)Fanconi anemia pathway - Homo sapiens (human)HDR through Single Strand Annealing (SSA)DNA Double-Strand Break Repair Homology Directed Repair HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)Formation of Incision Complex in GG-NER Nucleotide Excision Repair Global Genome Nucleotide Excision Repair (GG-NER)Dual Incision in GG-NER

via MyGene.info

Gene · Ensembl

ERCC excision repair 4, endonuclease catalytic subunit

Symbol: ERCC4
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:13,920,138-13,952,348
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Protein · UniProt

Cell cycle checkpoint protein RAD1

Gene: RAD1
Organism: Homo sapiens (Human)
Length: 282 aa
Molecular mass: 31,827 Da
Evidence: 1: Evidence at protein level

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proce…

3D-structureAlternative splicingDNA damageDNA repairNucleusProteomics identificationReference proteome

View on UniProt →

Swiss-Prot (reviewed) · via UniProt