紅血球生成素
Also known as EPO, uniprot:P01588, epoetin
Erythropoietin (; EPO), also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow. Low levels of EPO (around 10 mU/mL) are constantly secreted in sufficient quantities to compensate for normal red blood cell turnover. Common causes of cellular hypoxia resulting in elevated levels of EPO (up to 10 000 mU/mL) include any anemia, and hypoxemia due to chronic lung disease.
AI overview
Erythropoietin (EPO) is a protein made mainly by the kidneys that tells your bone marrow to produce more red blood cells, especially when your body isn't getting enough oxygen. Your body uses it to maintain healthy red blood cell levels during normal conditions and ramps up production when conditions like anemia or lung disease reduce oxygen availability.
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Article · 中文
红细胞生成素（英語：Erythropoietin，简称EPO），或称促紅血球生成素，是一種糖蛋白激素，其控制紅血球生成，或紅血球的產生。在骨髓中它是紅血球前體細胞的一種細胞因子（蛋白質信號傳導分子）。人類的促紅細胞生成素有34kDa的分子量。人体的促红细胞生成素由肝脏和肾合成分泌。婴幼儿时期主要由肝脏合成，成年后主要由肾脏合成。它同时具有其他的生物功能。例如对大脑对神经受损的反应其重要作用，同时也参与伤口愈合过程。 促红细胞生成素因为层出不穷的禁药事件而为公众所知。注射人工合成的紅血球生成激素刺激剂（ESA）可以提高运动员的成绩。这种药物与人体自身合成的促红细胞生成素有微小的差别，比较容易被检测出。可是後來，新版禁藥可以與自身DNA結合，變得難以檢驗出來。
Abstract from DBpedia / Wikipedia · CC BY-SA