FAT4

Also known as CDHF14, CDHR11, FAT-J, FATJ, NBLA00548, VMLDS2, HKLLS2, FAT atypical cadherin 4

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.

Gene data

FAT4

Name: FAT atypical cadherin 4
Type: protein-coding
Position: 125,314,918–125,492,932 (+)
Aliases: CDHF14, CDHR11, FAT-J, FATJ, HKLLS2, NBLA00548, VMLDS2
Ensembl: ENSG00000196159
RefSeq RNA: NM_001291285.3, NM_001291303.3, NM_001437895.1, NM_001438396.1, NM_001438397.1
RefSeq protein: NP_001278214.1, NP_001278232.1, NP_001424824.1, NP_001425325.1, NP_001425326.1

The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014].

Gene Ontology

Biological process

cell adhesion homophilic cell-cell adhesion heterophilic cell-cell adhesion axonogenesis cerebral cortex development neurogenesis epithelial cell differentiation hippo signaling

Molecular function

calcium ion binding protein binding

Cellular component

plasma membrane plasma membrane adherens junction membrane extracellular exosome

Pathways

Hippo signaling pathway - multiple species - Homo sapiens (human)GDNF-RET signaling axis Development of ureteric collection system

via MyGene.info

Gene · Ensembl

FAT atypical cadherin 4

Symbol: FAT4
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:125,314,918-125,492,932
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 14377
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/79633
genomic end: 126414087
genomic start: 125314918
chromosome: human chromosome 4
cytogenetic location: 4q28.1
expressed in: tibia

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Clinical significance
References
Further reading

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.

FAT4 is associated with the Hippo signaling pathway.

Excerpted from Wikipedia’s “FAT4” article, available under the CC BY-SA 4.0 licence.