neurofibromin 2
Sign in to saveAlso known as merlin, NF2, moesin-ezrin-radixin like, Neurofibromin-2, neurofibromin 2 (bilateral acoustic neuroma), schwannomin, moesin-ezrin-radixin-like protein, schwannomerlin
mammalian protein found in Homo sapiens
Protein · UniProt
Merlin
- Gene
- NF2
- Organism
- Homo sapiens (Human)
- Length
- 595 aa
- Molecular mass
- 69,690 Da
- Evidence
- 1: Evidence at protein level
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquiti…
Swiss-Prot (reviewed) · via UniProt
Research
1,048 papers- Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling.Nature · 2019
- Neurofibromatosis.Annual review of pathology · 2007
- PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation.Science (New York, N.Y.) · 2024
- Targeted next-generation sequencing for differential diagnosis of neurofibromatosis type 2, schwannomatosis, and meningiomatosis.Neuro-oncology · 2018
- The structure of neurofibromin isoform 2 reveals different functional states.Nature · 2021
via PubMed
Clinical Trials
76 registered- RECRUITINGNeurofibromatosis (NF) Registry PortalThe Children's Tumor Foundation · NCT01885767
- PHASE2COMPLETEDPhase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular SchwannomasUniversity of Alabama at Birmingham · NCT01767792
- UNKNOWNCutaneous and Mucosal Manifestations of Neurofribromatosis Type 2 in Children Under 15Centre Hospitalier Universitaire de Nice · NCT03893643
- NAUNKNOWNVestibular Precision: Physiology & PathophysiologyMassachusetts Eye and Ear Infirmary · NCT04890132
- PHASE2COMPLETEDAZD2014 In NF2 Patients With Progressive or Symptomatic MeningiomasMassachusetts General Hospital · NCT02831257
- UNKNOWNNF2 Natural History ConsortiumHouse Ear Institute · NCT00004483
Wikidata facts
- Instance of
- protein
Show 2 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P35240
via Wikidata · CC0