FBL

Name

fibrillarin rRNA 2'-O-methyltransferase

Type

protein-coding

Position

39,834,443–39,846,440 (−)

Aliases

FIB, FLRN, Nop1, RNU3IP1

Ensembl

ENSG00000105202

RefSeq RNA

NM_001436.4, XM_005258651.3, XM_011526623.3, XM_054320187.1, XM_054320188.1

RefSeq protein

NP_001427.2, XP_005258708.1, XP_011524925.1, XP_054176162.1, XP_054176163.1

This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

fibrillarin

Symbol

FBL

Biotype

Protein coding

Organism

Homo sapiens

Location

19:39,834,443-39,846,440

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein FBL PDB 2ipx.png

via Wikidata · CC0