DDX5

Also known as G17P1, HLR1, HUMP68, p68, DEAD-box helicase 5

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

In the Vinony graph

Within Vinony's link graph, DDX5 is referenced by 12 other articles, and connects out to PubMed, Ensembl genome database project and translation elongation factor.

It sits within the topics EC 3.6.4 and Genes on human chromosome 17.

Its subject is documented across 4 Wikipedia language editions.

Gene data

DDX5

Name: DEAD-box helicase 5
Type: protein-coding
Position: 64,498,253–64,508,199 (−)
Aliases: G17P1, HLR1, HUMP68, p68
Ensembl: ENSG00000108654
RefSeq RNA: NM_001320595.2, NM_001320596.3, NM_001320597.2, NM_004396.5, XM_047435513.1
RefSeq protein: NP_001307524.1, NP_001307525.1, NP_001307526.1, NP_004387.1, XP_047291469.1

This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017].

Pathways

Spliceosome - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Proteoglycans in cancer - Homo sapiens (human)Signal Transduction Disease Disease SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription cofactors Metabolism of proteins

via MyGene.info

Gene · Ensembl

DEAD-box helicase 5

Symbol: DDX5
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:64,498,253-64,508,199
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: DEAD BOX 5.png

Show 7 more facts

HomoloGene ID: 1655
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1655
chromosome: human chromosome 17
genomic start: 64498254
genomic end: 62504317
cytogenetic location: 17q23.3

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

== Function ==

Excerpted from Wikipedia’s “DDX5” article, available under the CC BY-SA 4.0 licence.