Nucleolar protein 12 is a protein that in humans is encoded by the NOL12 gene. Human NOL12 has been shown to localize in the nucleolus and regulate nucleolar structure and homeostasis by maintaining the levels of multi-functional fibrillarin and nucleolin proteins. Its deficiency leads to p53 activation resulting in G2 arrest of cell. Nol12 or hNol12 drives p53 induced cell senescence suggesting its important role in aging. Human Nol12 is also required for ribosome maturation and genome integrity.
Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Nucleolar protein 12 is a protein that in humans is encoded by the NOL12 gene. Human NOL12 has been shown to localize in the nucleolus and regulate nucleolar structure and homeostasis by maintaining the levels of multi-functional fibrillarin and nucleolin proteins. Its deficiency leads to p53 activation resulting in G2 arrest of cell. Nol12 or hNol12 drives p53 induced cell senescence suggesting its important role in aging. Human Nol12 is also required for ribosome maturation and genome integrity.
== Nol12 Family ==
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).