FGF19
Sign in to saveAlso known as fibroblast growth factor 19
Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.
Gene data
FGF19- Name
- fibroblast growth factor 19
- Type
- protein-coding
- Position
- 69,698,232–69,704,660 (−)
- Ensembl
- ENSG00000162344
- RefSeq RNA
- NM_005117.3
- RefSeq protein
- NP_005108.1
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
fibroblast growth factor 19
- Symbol
- FGF19
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:69,698,232-69,704,660
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein FGF19 PDB 1pwa.png
Show 5 more facts
- HomoloGene ID
- 3754
- exact match
- identifiers.org/ncbigene/9965
- genomic end
- 69704022
- genomic start
- 69698238
- cytogenetic location
- 11q13.3
via Wikidata · CC0
~4 min read
Article
5 sectionsContents
- Functions
- Role as a cancer promoter
- Clinical significance
- References
- Further reading
Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.
== Functions ==