فاکتور ۲۳ رشد فیبروبلاست
Sign in to saveAlso known as ADHR, FGFN, HPDR2, HYPF, PHPTC, fibroblast growth factor 23, HFTC2
protein-coding gene in the species Homo sapiens
Gene data
FGF23- Name
- fibroblast growth factor 23
- Type
- protein-coding
- Position
- 4,368,227–4,379,713 (−)
- Aliases
- ADHR, FGFN, HFTC2, HPDR2, HYPF, PHPTC
- Ensembl
- ENSG00000118972
- RefSeq RNA
- NM_020638.3
- RefSeq protein
- NP_065689.1
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
fibroblast growth factor 23
- Symbol
- FGF23
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:4,368,227-4,379,713
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein FGF23 PDB 2p39.png
Show 8 more facts
- HomoloGene ID
- 10771
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8074
- genomic end
- 4379712
- genomic start
- 4477393
- chromosome
- human chromosome 12
- cytogenetic location
- 12p13.32
- expressed in
- blood
via Wikidata · CC0