Skip to content
Vinony
English
EnglishDeutschEspañolFrançaisItalianoNederlandsPortuguêsSvenskaالعربية
GeneQ14889529· pop 5· linked from 369 articles

FGF3

Sign in to save

Also known as HBGF-3, INT2, fibroblast growth factor 3

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

Gene data

FGF3
Name
fibroblast growth factor 3
Type
protein-coding
Position
69,809,968–69,819,416 (−)
Aliases
HBGF-3, INT2
Ensembl
ENSG00000186895
RefSeq RNA
NM_005247.4
RefSeq protein
NP_005238.1

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)Calcium signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Regulation of actin cytoskeleton - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Melanoma - Homo sapiens (human)Breast cancer - Homo sapiens (human)Gastric cancer - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

fibroblast growth factor 3

Symbol
FGF3
Biotype
Protein coding
Organism
Homo sapiens
Location
11:69,809,968-69,819,416
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
3841
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/2248
chromosome
human chromosome 11
genomic start
69809968
genomic end
69819416
cytogenetic location
11q13.3
expressed in
dorsolateral prefrontal cortex
Sources (7)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • Clinical significance
  • Interactions
  • References
  • Further reading

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

== Function ==

Excerpted from Wikipedia’s “FGF3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0