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成纤维细胞
Sign in to saveAlso known as fibroblasts
A fibroblast is a type of biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural framework (stroma) for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals.
Key facts
- Cell.Name
- Fibroblast
- Cell.Latin
- fibroblastus
- Cell.Image
- NIH 3T3.jpg
- Cell.Caption
- NIH/3T3 Fibroblasts in cell culture
- Cell.Function
- Extracellular matrix and collagen creation
- Cell.Location
- Connective tissue
via Wikipedia infobox
Research
403,995 papers- A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues.Nature immunology · 2025
- Lymph node fibroblast-produced extracellular matrix shapes immune function.Trends in immunology · 2025
- Different fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signalling in murine ileitis.Nature communications · 2025
- Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer.Cancer cell · 2022
- The fibroblast epigenome underlies SS18::SSX-mediated transformation in synovial sarcoma.Nature communications · 2025
via PubMed
Wikidata facts
- Instance of
- cell type
- Image
- Fibroblast focus.jpg
Show 3 more facts
- Commons category
- Fibroblasts
- native label
- fibroblastus
- has characteristic
- Hayflick limit
via Wikidata · CC0
Article · 中文
成纤维细胞（fibroblast），或称纤维母细胞，是一种存在于蜂窝组织或纤维结缔组织中的梭形细胞，能够分泌构成细胞外基质的结构蛋白的细胞，最初由德国病理学家鲁道夫·菲尔绍与法国解剖学家于19世纪中叶描述。成纤维细胞与伤口愈合、纤维化等生理学或病理学过程密切相关。组织学中一般将结缔组织中活跃分泌细胞外基质的细胞称为成纤维细胞，而相对不活跃的纤维细胞则可能是成纤维细胞的前体细胞。 成纤维细胞是一类异质性很强的细胞，且没有明确的表面标记物可用于定义成纤维细胞类群。不同成纤维细胞之间可能发育来源不尽相同，且发挥截然不同的生物学功能。
Abstract from DBpedia / Wikipedia · CC BY-SA