Fibronectin 1
Sign in to savethumb|right|400px|The modular structure of fibronectin and its binding domains Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).
Article
11 sectionsContents
- Structure
- Function
- Matrix assembly
- Role in cancer
- Role in wound healing
- Fibronectin genetic variation as a protective factor against Alzheimer's disease
- Interactions
- See also
- References
- Further reading
- External links
thumb|right|400px|The modular structure of fibronectin and its binding domains Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).
Fibronectin exists as a protein dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds. The fibronectin protein is produced from a single gene, but alternative splicing of its pre-mRNA leads to the creation of several isoforms.