FKBP3
Sign in to saveAlso known as FKBP-25, FKBP-3, FKBP25, PPIase, FK506 binding protein 3, FKBP prolyl isomerase 3
FK506-binding protein 3 also known as FKBP25 is a protein that in humans is encoded by the FKBP3 gene.
Gene data
FKBP3- Name
- FKBP prolyl isomerase 3
- Type
- protein-coding
- Position
- 45,115,599–45,135,319 (−)
- Aliases
- FKBP-25, FKBP-3, FKBP25, PPIase
- Ensembl
- ENSG00000100442
- RefSeq RNA
- NM_002013.4, XM_011536565.4, XM_054375579.1, XM_054375580.1
- RefSeq protein
- NP_002004.1, XP_011534867.1, XP_054231554.1, XP_054231555.1
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008].
Gene Ontology
Molecular function
via MyGene.info
Gene · Ensembl
FKBP prolyl isomerase 3
- Symbol
- FKBP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:45,112,188-45,135,319
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein FKBP3 PDB 1pbk.png
Show 5 more facts
- HomoloGene ID
- 1525
- exact match
- identifiers.org/ncbigene/2287
- genomic end
- 45604522
- genomic start
- 45115599
- cytogenetic location
- 14q21.2
Sources (3)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
FK506-binding protein 3 also known as FKBP25 is a protein that in humans is encoded by the FKBP3 gene.
== Function ==