HDAC2

Name

histone deacetylase 2

Type

protein-coding

Position

113,923,388–114,011,308 (−)

Aliases

HD2, KDAC2, RPD3, YAF1

Ensembl

ENSG00000196591

RefSeq RNA

NM_001527.4, NR_033441.2, NR_073443.2, XM_047418692.1, XM_054355267.1

RefSeq protein

NP_001518.3, XP_047274648.1, XP_054211242.1

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].

via MyGene.info

Gene · Ensembl

histone deacetylase 2

Symbol

HDAC2

Biotype

Protein coding

Organism

Homo sapiens

Location

6:113,923,388-114,011,308

Strand

Reverse (−)

Assembly

GRCh38

• HDAC2 promotes autophagy-associated HCC malignant progression by transcriptionally activating LAPTM4B.Cell death & disease · 2024
• HDAC2 as a target for developing anti-cancer drugs.Computational and structural biotechnology journal · 2023
• Discovery of novel and potent dual-targeting AXL/HDAC2 inhibitors for colorectal cancer treatment via structure-based pharmacophore modelling, virtual screening, and molecular docking, molecular dynamics simulation studies, and biological evaluation.Journal of enzyme inhibition and medicinal chemistry · 2024
• A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis.Genome biology · 2024
• Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer.Clinical and translational medicine · 2024

via PubMed