fluconazole

Also known as 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol, 2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol

Fluconazole is an antifungal medication used for a number of fungal infections. These include candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. It is also used to prevent candidiasis in those who are at high risk such as following organ transplantation, low birth weight babies, and those with low blood neutrophil counts. It is given either by mouth or by injection into a vein.

Key facts

Drug.KEGG: D00322
Drug.KEGG2: C07002
Drug.ChEBI: 46081
Drug.ChEMBL: 106
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.Watchedfields: changed
Drug.verifiedrevid: 456485284
Drug.image: Fluconazole skeletal formula.svg
Drug.image_class: skin-invert-image
Drug.width: 185
Drug.image2: Fluconazole ball-and-stick model.png
Drug.image_class2

~10 min read

Article

12 sections

Contents

Medical uses
Resistance
Combating resistance
Contraindications
Side effects
Interactions
Pharmacology
Pharmacodynamics
Pharmacokinetics
History
References
Further reading

Common side effects include vomiting, diarrhea, rash, and increased liver enzymes. Serious side effects may include liver problems, QT prolongation, and seizures. Use during pregnancy may increase the risk of miscarriage or birth defects. Fluconazole is in the azole antifungal family of medication. It is believed to work by affecting the fungal cellular membrane.