File:Losartan_structure.svg · Wikimedia Commons · See Wikimedia Commons
losartan
Sign in to saveAlso known as DuP 753, MK-954, 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole, (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol, DuP 89
Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys. Besides hypertension, it is also used in diabetic kidney disease, heart failure, and left ventricular enlargement. It comes as a tablet that is taken by mouth. It may be used alone or in addition to other blood pressure medication. Up to six weeks may be required for the full effects to occur.
OverviewAI-generated
Losartan is a chemical compound with the formula C₂₂H₂₃ClN₆O. It has a mass of 422.162 and a weight of 422.9. The defined daily dose for this substance is 50. Its canonical SMILES notation is CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl.
Chemical properties of losartan include an xlogp value of 4.3 and a topological polar surface area of 92.5. The molecule contains two hydrogen bond donors and five hydrogen bond acceptors, with a charge of 0. The InChIKey for the compound is PSIFNNKUMBGKDQ-UHFFFAOYSA-N.
Losartan is associated with a PubMed query count of 11351. It is referenced by 268 other encyclopedia articles. A Commons category exists for the subject.
Synthesized by Vinony from 17 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.verifiedrevid
- 458612349
- Drug.image
- Losartan structure.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula
- Drug.width
- 200
- Drug.image2
- Losartan-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model
- Drug.tradename
- Cozaar, others
- Drug.MedlinePlus
- a695008
- Drug.DailyMedID
- Losartan
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.class
- Angiotensin II receptor antagonist
- Drug.ATC_prefix
- C09
- Drug.ATC_suffix
- CA01
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C22H23ClN6O
- Molecular weight
- 422.9 g/mol
- IUPAC name
- [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
- SMILES
- CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
- InChIKey
- PSIFNNKUMBGKDQ-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 92.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
11,351 papers- Clinical pharmacokinetics of losartan.Clinical pharmacokinetics · 2005
- Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
- Hyperuricemia and Gout: The Role of Losartan.The Senior care pharmacist · 2023
- Topical Losartan in the Management of Corneal Scarring Fibrosis: Update on Dosage, Efficacy, and Potential Epithelial Toxicity.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2025
- Topical Losartan in the Treatment of Stromal Scarring After Refractive Surgery.Journal of refractive surgery (Thorofare, N.J. : 1995) · 2025
via PubMed
~11 min read
Encyclopedic overview
13 sectionsContents
- Chemistry
- Medical uses
- Adverse effects
- Pregnancy
- Overdose
- Interactions
- Contamination
- Mechanism of action
- Pharmacokinetics
- History
- References
- Further reading
- External links
{{Infobox drug | verifiedrevid = 458612349 | image = Losartan structure.svg | image_class = skin-invert-image | alt = Skeletal formula | width = 200 | image2 = Losartan-from-xtal-3D-bs-17.png | image_class2 = bg-transparent | alt2 = Ball-and-stick model | width2 = | caption =
| pronounce = | tradename = Cozaar, others | Drugs.com = | MedlinePlus = a695008 | DailyMedID = Losartan | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = Angiotensin II receptor antagonist | ATC_prefix = C09 | ATC_suffix = CA01 | ATC_supplemental =
Excerpted from Wikipedia’s “losartan” article, available under the CC BY-SA 4.0 licence.