fluticasone

Key facts

Drug.Verifiedfields

changed

Drug.Watchedfields

changed

Drug.verifiedrevid

458449795

Drug.image

Fluticasone.svg

Drug.image_class

skin-invert-image

Drug.width

200

Drug.routes_of_administration

Intranasal, inhalation, topical

Drug.ATC_prefix

D07

Drug.ATC_suffix

AC17

Drug.legal_CA

OTC

Drug.bioavailability

0.51% (Intranasal)

Drug.protein_bound

91.0%

Drug.metabolism

IntranasalLiver (CYP3A4-mediated)

Drug.elimination_half life

10 hours

Drug.excretion

Kidney

Drug.IUPHAR_ligand

6699

Drug.CAS_number

90566-53-3

Drug.PubChem

5311101

via Wikipedia infobox

Chemical data

Formula

C22H27F3O4S

Molecular weight

444.5 g/mol

IUPAC name

S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate

SMILES

C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)SCF)O)C)O)F)C)F

InChIKey

MGNNYOODZCAHBA-GQKYHHCASA-N

XLogP

3.2

Polar surface area

99.9 Ų

H-bond donors

2

H-bond acceptors

8

Formal charge

0

via PubChem

• Fluticasone/formoterol compared with other ICS/LABAs in asthma: a systematic review.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022
• Salmeterol/fluticasone propionate combination.Drugs · 1999
• Fluticasone propionate: safety profile.Cutis · 1996
• Evaluation of fluticasone propionate/salmeterol for the treatment of COPD: a systematic review.Expert review of respiratory medicine · 2020
• Fluticasone furoate: CAPTAIN of fluticasones in type 2 inflammatory asthma.Respirology (Carlton, Vic.) · 2022

via PubMed