tachyphylaxis
Sign in to saveTachyphylaxis (from Ancient Greek , 'rapid', and , 'protection') is a medical term describing an acute, sudden decrease in response to a drug after its administration (i.e., a rapid and short-term onset of drug tolerance). It can occur after an initial dose or after a series of small doses. Increasing the dose of the drug may be able to restore the original response.
Research
3,349 papers- Tachyphylaxis in major depressive disorder: A review of the current state of research.Journal of affective disorders · 2019
- Tachyphylaxis and desensitization depression.CNS spectrums · 2021
- Tachyphylaxis.Industrial medicine & surgery · 1951
- Tachyphylaxis/ tolerance to antidepressive medications: a review.The Israel journal of psychiatry and related sciences · 2011
- Tachyphylaxis to cisatracurium--case reports and literature review.Middle East journal of anaesthesiology · 2008
via PubMed
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Encyclopedic overview
14 sectionsContents
- Characteristics
- Molecular interaction
- Examples
- Psychedelics
- Opioids
- Beta-2 agonists
- Nicotine
- Methylphenidate
- Other examples
- Intervention and reversal
- Intranasal decongestants
- See also
- References
- External links
Tachyphylaxis (from Ancient Greek , 'rapid', and , 'protection') is a medical term describing an acute, sudden decrease in response to a drug after its administration (i.e., a rapid and short-term onset of drug tolerance). It can occur after an initial dose or after a series of small doses. Increasing the dose of the drug may be able to restore the original response.
==Characteristics== Tachyphylaxis is characterized by the rate sensitivity: the response of the system depends on the rate with which a stimulus is presented. To be specific, a high-intensity prolonged stimulus or often-repeated stimulus may bring about a diminished response also known as desensitization.
Excerpted from Wikipedia’s “tachyphylaxis” article, available under the CC BY-SA 4.0 licence.