FMO2
Sign in to saveAlso known as FMO1B1, flavin containing monooxygenase 2, flavin containing dimethylaniline monoxygenase 2
Flavin-containing monooxygenase 2 (FMO2), also known as dimethylaniline monooxygenase [N-oxide-forming] 2, is a mammalian enzyme that in humans is encoded by the FMO2 gene. The gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.
Gene data
FMO2- Name
- flavin containing dimethylaniline monoxygenase 2
- Type
- protein-coding
- Position
- 171,185,249–171,212,686 (+)
- Aliases
- FMO1B1
- Ensembl
- ENSG00000094963
- RefSeq RNA
- NM_001301347.2, NM_001365900.2, NM_001426376.1, NM_001426378.1, NM_001426379.1
- RefSeq protein
- NP_001288276.1, NP_001352829.1, NP_001413305.1, NP_001413307.1, NP_001413308.1
This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
flavin containing dimethylaniline monoxygenase 2
- Symbol
- FMO2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:171,185,249-171,212,686
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Flavin-containing monooxygenase 2 (FMO2), also known as dimethylaniline monooxygenase [N-oxide-forming] 2, is a mammalian enzyme that in humans is encoded by the FMO2 gene. The gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.
FMO2 is a member of the family of flavin-containing monooxygenases, NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. It catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate.
Excerpted from Wikipedia’s “FMO2” article, available under the CC BY-SA 4.0 licence.