Gene data
FMOD- Name
- fibromodulin
- Type
- protein-coding
- Aliases
- FM, SLRR2E
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
via MyGene.info
Gene · Ensembl
fibromodulin
- Symbol
- FMOD
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:203,340,441-203,351,758
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 1530
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2331
- genomic end
- 203351758
- genomic start
- 203309756
- chromosome
- human chromosome 1
- cytogenetic location
- 1q32.1
- expressed in
- synovial joint
Sources (3)
via Wikidata · CC0
Article · العربية
Fibromodulin (Fibromodulin) هوَ بروتين يُشَفر بواسطة جين Fibromodulin في الإنسان.
Abstract from DBpedia / Wikipedia · CC BY-SA