thrombopoietin
Sign in to saveAlso known as megakaryocyte stimulating factor, c-mpl ligand, megakaryocyte colony-stimulating factor, ML, MPL ligand, MGDF, myeloproliferative leukemia virus oncogene ligand, prepro-thrombopoietin
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene.
Protein · UniProt
Thrombopoietin
- Gene
- THPO
- Organism
- Homo sapiens (Human)
- Length
- 353 aa
- Molecular mass
- 37,823 Da
- Evidence
- 1: Evidence at protein level
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
120 registered- PHASE2COMPLETEDA Study to Assess the Safety and Efficacy of Eltrombopag in Japanese Subjects With Refractory, Moderate or More Severe Aplastic AnemiaNovartis Pharmaceuticals · NCT02148133
- COMPLETEDA Retrospective Chart Review of Thirty Three Children Who Have Received Clinical Treatment With Either Romiplostim or Eltrombopag From 2009-2013Weill Medical College of Cornell University · NCT01974232
- NARECRUITINGRomiplostim for Oral TPO-RA Resistant ITPThe First Affiliated Hospital of Soochow University · NCT07612319
- PHASE2COMPLETEDA Phase 2 Study to Evaluate the Efficacy and Safety of AMG531 in Aplastic AnemiaKyowa Kirin Korea Co., Ltd. · NCT02094417
- PHASE3NOT_YET_RECRUITINGStudy on the Short-term Efficacy and Safety of Recombinant Human Thrombopoietin Combined With Immunosuppressant Sequential Eltrombopag Ethanolamine Dry Suspension in the Treatment of SAA/TD-NSAAPeking Union Medical College Hospital · NCT07001397
- PHASE3COMPLETEDrhTPO Combining Rituximab Versus Low-dose Rituximab in Management of ITPShandong University · NCT01525836
Wikidata facts
- Instance of
- protein
- Image
- Protein THPO PDB 1v7m.png
Show 3 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P40225
- Commons category
- Thrombopoietins
via Wikidata · CC0
~4 min read
Encyclopedic overview
8 sectionsContents
- Genetics
- Function and regulation
- Therapeutic use
- Discovery
- See also
- References
- Further reading
- External links
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene.
Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets.
Excerpted from Wikipedia’s “thrombopoietin” article, available under the CC BY-SA 4.0 licence.