FNIP1
Sign in to saveAlso known as folliculin interacting protein 1, IMD93
Folliculin-interacting protein 1 (FNIP1) functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. FNIP1 acts as a scaffold to load FLCN onto Hsp90. FNIP1 is also involved in chaperoning of both kinase and non-kinase clients.
In the Vinony graph
Vinony's link graph records 4 inbound references to FNIP1, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.
Vinony files it under Genes on human chromosome 5 and Human proteins.
Vinony links it to 5 Wikipedia language editions.
Gene data
FNIP1- Name
- folliculin interacting protein 1
- Type
- protein-coding
- Aliases
- IMD93
This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017].
via MyGene.info
Gene · Ensembl
folliculin interacting protein 1
- Symbol
- FNIP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:131,641,714-131,797,041
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 28173
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/96459
- genomic end
- 131797017
- genomic start
- 130977407
- chromosome
- human chromosome 5
- cytogenetic location
- 5q31.1
- expressed in
- Achilles tendon
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Co-chaperone function
- Post-translational regulation
- Clinical significance
- References
Folliculin-interacting protein 1 (FNIP1) functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. FNIP1 acts as a scaffold to load FLCN onto Hsp90. FNIP1 is also involved in chaperoning of both kinase and non-kinase clients.
== Co-chaperone function ==
Excerpted from Wikipedia’s “FNIP1” article, available under the CC BY-SA 4.0 licence.