HSPA1A
Sign in to saveAlso known as HEL-S-103, HSP70-1, HSP70-1A, HSP70I, HSP72, HSPA1, HSP70.1, heat shock protein family A (Hsp70) member 1A
Heat shock 70 kDa protein 1, also termed Hsp72, is a protein that in humans is encoded by the HSPA1A gene. As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. In addition, Hsp72 also facilitates DNA repair. Its functions contribute to biological processes including signal transduction, apoptosis, protein homeostasis, and cell growth and differentiation. It has been associated with an extensive number of cancers, neurodegenerative diseases, cell sen
Gene data
HSPA1A- Name
- heat shock protein family A (Hsp70) member 1A
- Type
- protein-coding
- Chromosome
- HSCHR6_MHC_QBL_CTG1
- Position
- 3,071,292–3,073,774 (+)
- Aliases
- HEL-S-103, HSP70, HSP70-1, HSP70-1A, HSP70-2, HSP70.1, HSP70.2, HSP70I, HSP72, HSPA1
- Ensembl
- ENSG00000234475
- RefSeq RNA
- NM_005345.6
- RefSeq protein
- NP_005336.3
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
heat shock protein family A (Hsp70) member 1A
- Symbol
- HSPA1A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_DBB_CTG1:3,063,243-3,065,725
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HSPA1A PDB 1hjo.png
Show 8 more facts
- HomoloGene ID
- 74294
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3303
- genomic end
- 31798031
- genomic start
- 31815543
- chromosome
- human chromosome 6
- cytogenetic location
- 6p21.33
- expressed in
- substantia nigra
Sources (4)
via Wikidata · CC0
~9 min read
Encyclopedic overview
8 sectionsContents
- Structure
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
Heat shock 70 kDa protein 1, also termed Hsp72, is a protein that in humans is encoded by the HSPA1A gene. As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. In addition, Hsp72 also facilitates DNA repair. Its functions contribute to biological processes including signal transduction, apoptosis, protein homeostasis, and cell growth and differentiation. It has been associated with an extensive number of cancers, neurodegenerative diseases, cell senescence and aging, and inflammatory diseases such as Diabetes mellitus type 2 and rheumatoid arthritis.
== Structure ==
Excerpted from Wikipedia’s “HSPA1A” article, available under the CC BY-SA 4.0 licence.