Also known as ALKBH9, GDFD, BMIQ14, fat mass and obesity associated, FTO, alpha-ketoglutarate dependent dioxygenase
protein-coding gene in the species Homo sapiens
Gene data
FTO- Name
- FTO alpha-ketoglutarate dependent dioxygenase
- Type
- protein-coding
- Position
- 53,701,692–54,158,512 (+)
- Aliases
- ALKBH9, BMIQ14, GDFD, IFEX9
- Ensembl
- ENSG00000140718
- RefSeq RNA
- NM_001080432.3, NM_001363891.2, NM_001363894.2, NM_001363896.2, NM_001363897.2
- RefSeq protein
- NP_001073901.1, NP_001350820.1, NP_001350823.1, NP_001350825.1, NP_001350826.1
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
FTO alpha-ketoglutarate dependent dioxygenase
- Symbol
- FTO
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:53,701,692-54,158,512
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI