single-nucleotide polymorphism
Sign in to saveAlso known as single nucleotide variation, single nucleotide polymorphism, SNP, SNV, Snp, snp, Polymorphism, Single Nucleotide, point mutation
single nucleotide position in genomic DNA at which different sequence alternatives exist
Research
183,294 papers- Single Nucleotide Polymorphism-based Identification of Bacterial Artificial Chromosome-mediated Homologous Recombination.Frontiers in bioscience (Landmark edition) · 2024
- PCR-Based Detection Methods for Single-Nucleotide Polymorphism or Mutation: Real-Time PCR and Its Substantial Contribution Toward Technological Refinement.Advances in clinical chemistry · 2017
- Single-nucleotide polymorphism mapping.Methods in molecular biology (Clifton, N.J.) · 2006
- Research progress of single nucleotide polymorphism in stress urinary incontinence.European journal of obstetrics, gynecology, and reproductive biology · 2021
- [Research progress of single-nucleotide polymorphism in theTM6SF2 rs58542926].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2019
via PubMed
~25 min read
Encyclopedic overview
The upper DNA molecule differs from the lower DNA molecule at a single base-pair location (a G/A polymorphism) In genetics and bioinformatics, a single-nucleotide polymorphism (SNP /snɪp/; plural SNPs /snɪps/) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold.
For example, a G nucleotide present at a specific location in a reference genome may be replaced by an A in a minority of individuals. The two possible nucleotide variations of this SNP – G or A – are called alleles.
Excerpted from Wikipedia’s “single-nucleotide polymorphism” article, available under the CC BY-SA 4.0 licence.