GAB2
Sign in to saveAlso known as entrez:9846, GRB2 associated binding protein 2
GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene.
Gene data
GAB2- Name
- GRB2 associated binding protein 2
- Type
- protein-coding
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
via MyGene.info
Wikidata facts
- Image
- Protein GAB2 PDB 2VWF.png
Show 5 more facts
- HomoloGene ID
- 69067
- exact match
- identifiers.org/ncbigene/9846
- genomic end
- 78129394
- genomic start
- 78215293
- cytogenetic location
- 11q14.1
via Wikidata · CC0
~11 min read
Article
18 sectionsContents
- Discovery
- Structure
- Function
- Interactions
- AKT1
- CRKL
- Grb2
- PI3K
- PLCG2
- PTPN11
- RICS
- SHC1
- Clinical Implications
- Alzheimer's disease
- Cancer
- References
- Further reading
- External links
GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene.
GAB2 is a docking protein with a conserved, folded PH domain attached to the membrane and a large disordered region, which hosts interactions with signaling molecules. It is a member of the GAB/DOS family localized on the internal membrane of the cell. It mediates the interaction between receptor tyrosine kinases (RTKs) and non-RTK receptors serving as the gateway into the cell for activation of SHP2, Phosphatidylinositol 3-kinase (PI3K), Grb2, ERK, and AKT and acting as one of the first steps in these signaling pathways. GAB2 has been shown to be important in physiological functions such as growth in bone marrow and cardiac function. GAB2 has also been associated with many diseases including leukemia and Alzheimer's disease.