GAB2

Name

GRB2 associated binding protein 2

Type

protein-coding

Position

78,215,293–78,418,348 (−)

Ensembl

ENSG00000033327

RefSeq RNA

NM_012296.4, NM_080491.3, XM_024448782.2, XM_047427935.1, XM_047427936.1

RefSeq protein

NP_036428.1, NP_536739.1, XP_024304550.1, XP_047283891.1, XP_047283892.1

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009].

via MyGene.info

Gene · Ensembl

GRB2 associated binding protein 2

Symbol

GAB2

Biotype

Protein coding

Organism

Homo sapiens

Location

11:78,215,293-78,418,348

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein GAB2 PDB 2VWF.png

via Wikidata · CC0