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gastrin
ProteinQ407181· pop 44· linked from 276 articles

gastrin

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Also known as uniprot:P01350, preprogastrin, GAST

Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.

OverviewAI-generated

Gastrin is a human hormone encoded by the GAST gene. The protein has a length of 101 amino acids and a mass of 11394. It is characterized by keywords including 3D-structure, amidation, cleavage on a pair of basic residues, direct protein sequencing, and hormone. Evidence for its existence is at the protein level, and the entry is reviewed.

The subject is referenced by 276 other encyclopedia articles. Additionally, there are 50 clinical trials associated with the query for gastrin.

Synthesized by Vinony from 13 facts across 4 sources: Wikidata, ClinicalTrials.gov, UniProt, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Key facts

Protein family.Symbol
Gastrin
Protein family.Name
Gastrin
Protein family.Pfam
PF00918
Protein family.InterPro
IPR001651
Protein family.PROSITE
PDOC00232

via Wikipedia infobox

Protein · UniProt

Gastrin

Gene
GAST
Organism
Homo sapiens (Human)
Length
101 aa
Molecular mass
11,394 Da
Evidence
1: Evidence at protein level

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine

3D-structureAmidationCleavage on pair of basic residuesDirect protein sequencingHormonePhosphoproteinProteomics identificationPyrrolidone carboxylic acid
View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

50 registered

via ClinicalTrials.gov

Wikidata facts

Instance of
protein
Show 3 more facts
cell component
extracellular space
found in taxon
Homo sapiens
exact match
purl.uniprot.org/uniprot/P01350
Sources (3)

via Wikidata · CC0

~6 min read

Encyclopedic overview

18 sections
Contents
  • Physiology
  • Genetics
  • Synthesis
  • Release
  • Function
  • Factors influencing secretion
  • Physiologic
  • Gastric lumen
  • Paracrine
  • Nervous
  • Circulation
  • Pathophysiologic
  • Paraneoplastic
  • Role in disease
  • History
  • References
  • Further reading
  • External links

Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.

Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which in turn increases H+ release into the stomach cavity). Its release is stimulated by peptides in the lumen of the stomach.

Excerpted from Wikipedia’s “gastrin” article, available under the CC BY-SA 4.0 licence.

Gallery (2)

Available in 44 languages

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via Wikidata sitelinks · CC0