gastrin
Sign in to saveGastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.
Key facts
- Protein family.Symbol
- Gastrin
- Protein family.Name
- Gastrin
- Protein family.Pfam
- PF00918
- Protein family.InterPro
- IPR001651
- Protein family.PROSITE
- PDOC00232
via Wikipedia infobox
Article
18 sectionsContents
- Physiology
- Genetics
- Synthesis
- Release
- Function
- Factors influencing secretion
- Physiologic
- Gastric lumen
- Paracrine
- Nervous
- Circulation
- Pathophysiologic
- Paraneoplastic
- Role in disease
- History
- References
- Further reading
- External links
Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.
Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which in turn increases H+ release into the stomach cavity). Its release is stimulated by peptides in the lumen of the stomach.