pentagastrin

Also known as Peptavlon, ICI-50123, AY-6608

Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Key facts

Drug.Watchedfields: changed
Drug.verifiedrevid: 464198043
Drug.IUPAC_name: N-(tert-butoxycarbonyl)-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
Drug.image: Pentagastrin.svg
Drug.image_class: skin-invert-image
Drug.elimination_half life: 10 minutes or less
Drug.CAS_number: 5534-95-2
Drug.ATC_prefix: V04
Drug.ATC_suffix: CG04
Drug.PubChem: 9853654
Drug.IUPHAR_ligand: 870
Drug.DrugBank: DB00183
Drug.ChemSpiderID: 8029364
Drug.UNII: EF0NX91490
Drug.KEGG: D01631
Drug.ChEMBL: 1328
Drug.C: 37
Drug.H: 49

via Wikipedia infobox

Research

5,118 papers

Pentagastrin.The Medical letter on drugs and therapeutics · 1975
Pentagastrin-induced thrombocytopenia.Lancet (London, England) · 1985
Pentagastrin test for anxiety--psychophysiology and personality.Psychopharmacology · 2003
Pentagastrin has panic-inducing properties in obsessive compulsive disorder.Psychopharmacology · 1996
[Trophic effect of gastroenteric hormones pentagastrin and glucagon on the mucosa of the small intestine].Polski tygodnik lekarski (Warsaw, Poland : 1960) · 1989

via PubMed

~2 min read

Encyclopedic overview

4 sections

Contents

Pentagastrin stimulation test
Calcitonin test
See also
References

Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it may cause panic attacks.

Excerpted from Wikipedia’s “pentagastrin” article, available under the CC BY-SA 4.0 licence.

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