Structure via PubChem · Public domain (PubChem)
gemifloxacin
Sign in to saveAlso known as Factive, Gemifloxacin mesilate, Factiv, gemifloxacin mesylate
Gemifloxacin mesylate, sold under the brand name Factive among others, is a broad-spectrum quinolone antibacterial agent used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is taken by mouth. Vansen Pharma Inc. licensed the active ingredient from LG Life Sciences of Korea.
Chemical data
- Formula
- C18H20FN5O4
- Molecular weight
- 389.4 g/mol
- IUPAC name
- 7-[(4Z)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
- SMILES
- CO/N=C/1\CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F
- InChIKey
- ZRCVYEYHRGVLOC-HYARGMPZSA-N
- XLogP
- -0.7
- Polar surface area
- 121 Ų
- H-bond donors
- 2
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2003
- Admin. routes
- oral
- Indications
- rhinoscleroma, Helicobacter pylori infectious disease, bacterial disease, peritonitis
via ChEMBL · EBI
Research
533 papers- Gemifloxacin.2012
- Gemifloxacin.2006
- Gemifloxacin.Drugs · 2000
- Gemifloxacin.Drugs of today (Barcelona, Spain : 1998) · 2001
- Gemifloxacin for community-acquired pneumonia.Expert opinion on investigational drugs · 2008
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 389.149932
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₈H₂₀FN₅O₄
- isomeric SMILES
- CO/N=C/1\CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F
- canonical SMILES
- CON=C1CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F
- Commons category
- Gemifloxacin
- World Health Organisation international non-proprietary name
- gemifloxacin
- subject has role
- bactericide
- legal status (medicine)
- boxed warning
Sources (6)
via Wikidata · CC0
~4 min read
Encyclopedic overview
5 sectionsContents
- Common Uses (Indications)
- Microbiology
- Adverse effects
- Research
- References
Gemifloxacin mesylate, sold under the brand name Factive among others, is a broad-spectrum quinolone antibacterial agent used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is taken by mouth. Vansen Pharma Inc. licensed the active ingredient from LG Life Sciences of Korea.
==Common Uses (Indications)== Gemifloxacin is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions listed below. Acute bacterial exacerbation of chronic bronchitis caused by S. pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, or Moraxella catarrhalis Community-acquired pneumonia (of mild to moderate severity) caused by S. pneumoniae (including multi-drug resistant strains, Haemophilus influenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, Chlamydia pneumoniae, or Klebsiella pneumoniae
Excerpted from Wikipedia’s “gemifloxacin” article, available under the CC BY-SA 4.0 licence.