aminocoumarin
Sign in to saveAlso known as aminocoumarins
thumb|Skeletal formula of [[novobiocin]] Aminocoumarin is a class of antibiotics that act by an inhibition of the DNA gyrase enzyme involved in the cell division in bacteria. They are derived from Streptomyces species, whose best-known representative – Streptomyces coelicolor – was completely sequenced in 2002. The aminocoumarin antibiotics include: Novobiocin, Albamycin (Pharmacia And Upjohn) Coumermycin Clorobiocin
Research
2,586 papers- New aminocoumarin antibiotics as gyrase inhibitors.International journal of medical microbiology : IJMM · 2014
- Structural and functional dissection of aminocoumarin antibiotic biosynthesis: a review.Journal of structural and functional genomics · 2012
- The biosynthetic gene clusters of aminocoumarin antibiotics.Planta medica · 2006
- Genetically Encoded Aminocoumarin Lysine for Optical Control of Protein-Nucleotide Interactions in Zebrafish Embryos.ACS chemical biology · 2023
- Genome-mining-guided discovery of coumarubrin: A novel aminocoumarin-substituted rubromycin antibiotic.Journal of industrial microbiology & biotechnology · 2024
via PubMed
~2 min read
Encyclopedic overview
5 sectionsContents
- Structure
- Mechanism of action
- Resistance
- Clinical use
- References
thumb|Skeletal formula of [[novobiocin]] Aminocoumarin is a class of antibiotics that act by an inhibition of the DNA gyrase enzyme involved in the cell division in bacteria. They are derived from Streptomyces species, whose best-known representative – Streptomyces coelicolor – was completely sequenced in 2002. The aminocoumarin antibiotics include: Novobiocin, Albamycin (Pharmacia And Upjohn) Coumermycin Clorobiocin
==Structure== The core of aminocoumarin antibiotics is made up of a 3-amino-4,7-dihydroxycumarin ring, which is linked, e.g., with a sugar in 7-Position and a benzoic acid derivative in 3-Position.
Excerpted from Wikipedia’s “aminocoumarin” article, available under the CC BY-SA 4.0 licence.