Structure via PubChem · Public domain (PubChem)
marbofloxacin
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Marbofloxacin is a carboxylic acid derivative third generation fluoroquinolone antibiotic. It is used in veterinary medicine under the brand names Marbocyl, Forcyl, Marbo vet and Zeniquin. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon (CAS number 115550-35-1).
Chemical data
- Formula
- C17H19FN4O4
- Molecular weight
- 362.4 g/mol
- IUPAC name
- 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1,2-diazatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
- SMILES
- CN1CCN(CC1)C2=C(C=C3C4=C2OCN(N4C=C(C3=O)C(=O)O)C)F
- InChIKey
- BPFYOAJNDMUVBL-UHFFFAOYSA-N
- XLogP
- -0.5
- Polar surface area
- 76.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
576 papers- Marbofloxacin (2(nd) edition) (Veterinary Medicinal Products).Food safety (Tokyo, Japan) · 2023
- Marbofloxacin.Acta crystallographica. Section E, Structure reports online · 2012
- An immunochromatographic strip sensor for marbofloxacin residues.PloS one · 2024
- Pharmacokinetic enhancement of marbofloxacin by alpha-1-monolaurin pre-treatment in broiler chickens.Veterinary research forum : an international quarterly journal · 2024
- An Overview of Analytical Methods for the Quantification of Marbofloxacin in Pharmaceutical, Biological, and Food Matrixes.Journal of AOAC International · 2022
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 362.139
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₇H₁₉FN₄O₄
- canonical SMILES
- CN1CCN(CC1)C2=C(C=C3C4=C2OCN(N4C=C(C3=O)C(=O)O)C)F
- NCI Thesaurus ID
- C80640
- subject has role
- antibiotic
- World Health Organisation international non-proprietary name
- marbofloxacin
- medical condition treated
- cystitis
- Commons category
- Marbofloxacin
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Mechanism of action
- Activity
- Application
- Contraindications and side effects
- References
Marbofloxacin is a carboxylic acid derivative third generation fluoroquinolone antibiotic. It is used in veterinary medicine under the brand names Marbocyl, Forcyl, Marbo vet and Zeniquin. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon (CAS number 115550-35-1).
==Mechanism of action== Its mechanism of action is not thoroughly understood, but it is believed to be similar to the other fluoroquinolones by impairing the bacterial DNA gyrase which results in rapid bactericidal activity. The other proposed mechanisms include that it acts against nondividing bacteria and does not require protein and RNA synthesis, which block protein and RNA synthesis respectively.
Excerpted from Wikipedia’s “marbofloxacin” article, available under the CC BY-SA 4.0 licence.