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GeneQ18026212· pop 7· linked from 295 articles

GNA11

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Also known as FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2, G protein subunit alpha 11, HG1K

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.

Gene data

GNA11
Name
G protein subunit alpha 11
Type
protein-coding
Position
3,094,320–3,124,001 (+)
Aliases
FBH, FBH2, FHH2, GNA-11, HG1K, HHC2, HYPOC2
Ensembl
ENSG00000088256
RefSeq RNA
NM_002067.5
RefSeq protein
NP_002058.2

The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013].

Gene Ontology

Pathways

Calcium signaling pathway - Homo sapiens (human)cGMP-PKG signaling pathway - Homo sapiens (human)Vascular smooth muscle contraction - Homo sapiens (human)Gap junction - Homo sapiens (human)Cholinergic synapse - Homo sapiens (human)Long-term depression - Homo sapiens (human)Insulin secretion - Homo sapiens (human)GnRH signaling pathway - Homo sapiens (human)Aldosterone synthesis and secretion - Homo sapiens (human)Cortisol synthesis and secretion - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

G protein subunit alpha 11

Symbol
GNA11
Biotype
Protein coding
Organism
Homo sapiens
Location
19:3,094,320-3,124,001
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
20474
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/2767
genomic end
3123999
genomic start
3094362
chromosome
human chromosome 19
cytogenetic location
19p13.3
Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections
Contents
  • See also
  • References
  • Further reading

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.

==See also== Gq alpha subunit

Excerpted from Wikipedia’s “GNA11” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0