kinesin complex
Sign in to saveAlso known as kinesins, GO:0005871, kinesin (unspecified direction), kinesin, ATP-dependent microtubule motor
thumb|The kinesin dimer (red) attaches to, and moves along, microtubules (blue and green). thumb|Animation of kinesin "walking" on a [[microtubule. Protein domain dynamics can only now be seen by neutron spin echo spectroscopy.]] A kinesin is a protein complex belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases, a type of enzyme). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of c
Key facts
- Protein family.caption
- Crystallographic structure of the human kinesin motor domain depicted as a rainbow colored cartoon (N-terminus = blue, C-terminus = red) complexed with ADP (stick diagram, carbon = white, oxygen = red, nitrogen = blue, phosphorus = orange) and a magnesium ion (grey sphere).
- Protein family.Pfam
- PF00225
- Protein family.InterPro
- IPR001752
- Protein family.SMART
- SM00129
- Protein family.PROSITE
- PS50067
- Protein family.SCOP
- 1bg2
- Protein family.CDD
- cd00106
- Protein family.Symbol
- Kinesin motor domain
- Protein family.Name
- Kinesin motor domain
- Protein family.image
- Kinesin_motor_domain_1BG2.png
via Wikipedia infobox
Wikidata facts
Show 2 more facts
- exact match
- purl.obolibrary.org/obo/GO_0005871
- Commons category
- Kinesin
Sources (3)
via Wikidata · CC0
~14 min read
Article
15 sectionsContents
- Discovery
- Structure
- Overall structure
- Kinesin motor domain
- Basic kinesin regulation
- Cargo transport
- Direction of motion
- Mechanism of movement
- Theoretical modeling
- Mitosis
- Kinesin superfamily
- See also
- References
- Further reading
- External links
thumb|The kinesin dimer (red) attaches to, and moves along, microtubules (blue and green). thumb|Animation of kinesin "walking" on a [[microtubule. Protein domain dynamics can only now be seen by neutron spin echo spectroscopy.]] A kinesin is a protein complex belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases, a type of enzyme). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport, and intraflagellar transport. Most kinesins walk towards the plus end of a microtubule, which, in most cells, entails transporting cargo such as protein and membrane components from the center of the cell towards the periphery. This form of transport is known as anterograde transport. In contrast, dyneins are motor proteins that move toward the minus end of a microtubule in retrograde transport.
== Discovery == The first kinesins to be discovered were microtubule-based anterograde intracellular transport motors in 1985, based on their motility in cytoplasm extruded from the giant axon of the squid.