goserelin

Chemical data

Formula

C59H84N18O14

Molecular weight

1269.4 g/mol

IUPAC name

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

SMILES

CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NNC(=O)N)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6

InChIKey

BLCLNMBMMGCOAS-URPVMXJPSA-N

XLogP

-1.5

Polar surface area

496 Ų

H-bond donors

17

H-bond acceptors

16

Formal charge

0

via PubChem

• Goserelin ('Zoladex')--offering patients more choice in early breast cancer.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2004
• Clinical pharmacokinetics of goserelin.Clinical pharmacokinetics · 2000
• Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in benign gynaecological disorders.Drugs · 1996
• Goserelin: a review of its use in the treatment of early breast cancer in premenopausal and perimenopausal women.Drugs · 2005
• Goserelin. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in prostate cancer.Drugs & aging · 1995

via PubMed