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brompheniramine

Structure via PubChem · Public domain (PubChem)

EntityQ2606497· pop 17· linked from 1,097 articles

brompheniramine

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Also known as Bromfed®, brompheniramine maleate, Dimetapp®, 3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine, 3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine, 2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine, 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane, Veltane

Brompheniramine, sold under the brand name Dimetapp among others, is a first-generation antihistamine drug of the propylamine (alkylamine) class. It is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. Like the other first-generation drugs of its class, it is considered a sedating antihistamine.

Chemical data

Formula
C16H19BrN2
Molecular weight
319.24 g/mol
IUPAC name
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
SMILES
CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
InChIKey
ZDIGNSYAACHWNL-UHFFFAOYSA-N
XLogP
3.5
Polar surface area
16.1 Ų
H-bond donors
0
H-bond acceptors
2
Formal charge
0

via PubChem

Drug data · ChEMBL

Max clinical phase
Approved
Molecule type
Small molecule
First approval
1957
Admin. routes
oral, parenteral
Indications
allergic disease

via ChEMBL · EBI

Research

765 papers

via PubMed

Wikidata facts

Subclass of
chemical compound
Mass
318.073161
Has use
medication
Show 6 more facts
chemical formula
C₁₆H₁₉BrN₂
defined daily dose
24
medical condition treated
vasomotor rhinitis
canonical SMILES
CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
World Health Organisation international non-proprietary name
brompheniramine
Commons category
Brompheniramine
Sources (3)

via Wikidata · CC0

~3 min read

Encyclopedic overview

6 sections
Contents
  • Side effects
  • Pharmacology
  • Chemistry
  • History
  • Names
  • References

Brompheniramine, sold under the brand name Dimetapp among others, is a first-generation antihistamine drug of the propylamine (alkylamine) class. It is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. Like the other first-generation drugs of its class, it is considered a sedating antihistamine.

It was patented in 1948 and came into medical use in 1955. In 2023, the combination with dextromethorphan and pseudoephedrine was the 281st most commonly prescribed medication in the United States, with more than 700,000 prescriptions.

Excerpted from Wikipedia’s “brompheniramine” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0